Admixture Mapping of Obesity‐related Traits in African Americans: The Atherosclerosis Risk in Communities (ARIC) Study
Year: 2009
Type: article
Abstract: Obesity is an important cause of morbidity and mortality worldwide. In the United States, the prevalence of obesity is higher in African Americans than whites, even after adjustment for socioeconomic status (SES). This leads to the hypothesis that differences in genetic background may contribute to racial/ethnic differences in obesity-related traits. We tested this hypothesis by conducting a genome-wide admixture mapping scan using 1,350 ancestry-informative single-nucleotide polymorphisms (SNPs) in 3,531 self-identified blacks from the Atherosclerosis Risk in Communities (ARIC) study. We used these markers to estimate the overall proportions of European ancestry (PEAs) for each individual and then scanned for the association between PEA and obesity-related traits (both continuous and dichotomous) at each locus. The median (interquartile range) PEA was 0.151 (0.115). PEA was inversely correlated with continuous BMI, weight, and subscapular skinfold thickness, even after adjusting for socioeconomic factors. In contrast, PEA was positively correlated with BMI-adjusted waist circumference. Using admixture mapping on dichotomized traits, we identified a locus on 2p23.3 to be suggestively associated with BMI (locus-specific lod = 4.11) and weight (locus-specific lod = 4.07). After adjusting for global PEA, each additional copy of a European ancestral allele at the 2p23.3 peak was associated with a BMI decrease of approximately 0.92 kg/m(2) (P = 2.9 x 10(-5)). Further mapping in this region on chromosome 2 may be able to uncover causative variants underlying obesity, which may offer insights into the control of energy homeostasis.
Source: Obesity
DOI: 10.1038/oby.2009.282
Institutions: Johns Hopkins University, Taipei Veterans General Hospital, National Human Genome Research Institute, National Yang Ming University, Broad Institute, Harvard University, Massachusetts Institute of Technology, The University of Texas Health Science Center at Houston, University of North Carolina at Chapel Hill, University of Mississippi Medical Center
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funders: Johns Hopkins University, National Institutes of Health, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Center for Research Resources
Awards: G1045430581, G118440752, G1325221871, G136105103, Atherosclerosis Risk in Communities Study (ARIC), G215333750, Institute for Clinical and Translational Research (UL1), CCSP FIELD CENTER, G25881238, COMMUNITY AND COHORT SURVEILLANCE PROGRAM, CENTRAL HEMOSTATIS LABORATORY FOR CCSP, GENOTYPING FOR LOCATING HUMAN DISEASE GENES, G3236609591, G390162502, NHLBI DNA Re-sequencing and Genotyping Program -- Genotyping Center, G4145745212, G4176762999, Atherosclerosis Risk in Communities Study (ARIC), G4671189754, G4932516547, Population structure in whole-genome disease scans, G528395701, G5294359063, G5359555627, G5451084504, G5522185877, Atherosclerosis Risk in Communities Study (ARIC), G5780424650, G6203107232, G6204895930, Genetic Epidemiology of NAFLD and T2DM, G6576172577, G6860406196, G786153652, G793702358, G812579647, Admixture Mapping to Identify T2DM Genes in African Americans, G8486527673, G9000015747, G9000028264, G9000036580, G9000080822, G9000108254, G9000126117, G9000152345, G9000294209, UNC Center for Environmental Health and Susceptibility, Atherosclerosis Risk in Communities Study (ARIC)
OpenAlex ID: W2086276898