Work

A Highly Convergent Approach toward (−)-Brevenal

Year: 2020

Type: article

Abstract: Progress toward a highly convergent, asymmetric synthesis of brevenal is reported. Construction of the AB-ring and E-ring cyclic ether fragments was achieved through asymmetric alkylation/ring-closing metathesis strategies. A Horner-Wadsworth-Emmons olefination was used in a key bond-forming step to couple the advanced cyclic fragments and enable rapid access to the AB-E ring system.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/vvh5-ge50

Authors: Mattson, Anita E., Shamszad, Mariam, Crimmins, Michael T.

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Synthetic Organic Chemistry Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: G4702081312