Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
Year: 2008
Type: article
Abstract: Alcohol and tobacco consumption are well-recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk and family history of HNC and other cancers. We pooled individual-level data across 12 case-control studies including 8,967 HNC cases and 13,627 controls. We obtained pooled odds ratios (OR) using fixed and random effect models and adjusting for potential confounding factors. All statistical tests were two-sided. A family history of HNC in first-degree relatives increased the risk of HNC (OR=1.7, 95% confidence interval, CI, 1.2-2.3). The risk was higher when the affected relative was a sibling (OR=2.2, 95% CI 1.6-3.1) rather than a parent (OR=1.5, 95% CI 1.1-1.8) and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher, or limited to, in subjects exposed to tobacco. The OR rose to 7.2 (95% CI 5.5-9.5) among subjects with family history, who were alcohol and tobacco users. A weak but significant association (OR=1.1, 95% CI 1.0-1.2) emerged for family history of other tobacco-related neoplasms, particularly with laryngeal cancer (OR=1.3, 95% CI 1.1-1.5). No association was observed for family history of nontobacco-related neoplasms and the risk of HNC (OR=1.0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC.
Source: International Journal of Cancer
DOI: 10.1002/ijc.23848
Authors: Eva Negri, Paolo Boffetta, Julien Berthiller, Xavier Castellsague, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Eleonora Fabianova, Leticia Fernandez, Victor Wünsch‐Filho, Silvia Franceschi, Richard B. Hayes, Rolando Herrero, Sergio Koifman, Philip Lazarus, Juan J. Lence, Fabio Levi, Dana Mates, Elena Matos, Ana Menezes, Joshua Muscat, Jose Eluf‐Neto, Andrew F. Olshan, Peter Rudnai, Oxana Shangina, Erich M. Sturgis, Neonilia Szeszenia‐Dabrowska, Renato Talamini, Qingyi Wei, Deborah M. Winn, David Zaridze, Jolanta Lissowska, Zuo‐Feng Zhang, Gilles Ferro, Paul Brennan, Carlo La Vecchia, Mia Hashibe
Institutions: Mario Negri Institute for Pharmacological Research, Centre international de recherche sur le cancer, Institut Català d'Oncologia, Centro di Riferimento Oncologico, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Instituto de Oncología y Radiobiología, Escuela Nacional de Salud Pública, National Institutes of Health, National Cancer Institute, Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Pennsylvania State University, University of Lausanne, Universidad de Buenos Aires, Universidade Federal de Pelotas, Universidade de São Paulo, University of North Carolina at Chapel Hill, Agricultural Biotechnology Institute, Orszagos Kornyezetegeszsegugyi Intezet, Russian Cancer Research Center NN Blokhin, The University of Texas MD Anderson Cancer Center, Nofer Institute of Occupational Medicine, The Maria Sklodowska-Curie National Research Institute of Oncology, University of California, Los Angeles, University of Milan
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: European Commission, Fundação de Amparo à Pesquisa do Estado de São Paulo, Oncosuisse, Associazione Italiana per la Ricerca sul Cancro, National Institutes of Health, World Cancer Research Fund, National Institute on Drug Abuse, National Cancer Institute, National Institute of Environmental Health Sciences, Jonsson Comprehensive Cancer Center, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Fondo para la Investigación Científica y Tecnológica
Awards: HELICOBACTER PYLORI MALNUTRITION AND GASTRIC CANCER, G1158119171, Carolina Population Center, G1245777278, G1338312080, G1545164507, G1556079268, G1611099181, G1789099407, Molecular Epidemiology Cancer Training Program, G2067422786, G2789296392, CARCINOGEN METABOLIZING ENZYMES AND HEAD AND NECK CANCER, G2970275439, Molecular Epidemiology of DNA Repair in Head and Neck Cancer, TOBACCO AND CANCER RISK--DOSE, METABOLISM AND GENETICS, Estudo internacional de fatores ambientais, vírus e câncer de cavidade oral e de laringe, UCLA SPORE IN LUNG CANCER, G600161472, LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERS, Genetic Predictors for DNA Repair Phenotype in CMM, Epidemiology of protein glutathiolation, Molecular Epidemiology and Gene-Environment Interaction, G81204159, G8151339235, G8362657403, International Head and Neck Cancer Consortium, MARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERS, UNC Center for Environmental Health and Susceptibility
OpenAlex ID: W2033749430