Delivery of Multiple siRNAs Using Lipid-Coated PLGA Nanoparticles for Treatment of Prostate Cancer
Year: 2011
Type: article
Abstract: Nanotechnology can provide a critical advantage in developing strategies for cancer management and treatment by helping to improve the safety and efficacy of novel therapeutic delivery vehicles. This paper reports the fabrication of poly(lactic acid-co-glycolic acid)/siRNA nanoparticles coated with lipids for use as prostate cancer therapeutics made via a unique soft lithography particle molding process called Particle Replication In Nonwetting Templates (PRINT). The PRINT process enables high encapsulation efficiency of siRNA into neutral and monodisperse PLGA particles (32-46% encapsulation efficiency). Lipid-coated PLGA/siRNA PRINT particles were used to deliver therapeutic siRNA in vitro to knockdown genes relevant to prostate cancer.
Source: Nano Letters
DOI: 10.1021/nl2035354
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G1192852400, Carolina Center of Cancer Nanotechnology Excellence, G2560607304, Delivery of Biological Therapeutics: Using Engineered Particles and Novel Deliver, Carolina Center of Cancer Nanotechnology Excellence, Center for Environmentally Responsible Solvents and Processes, Engineered Organic Particles of Controlled Size, Shape and Surface Chemistry for
OpenAlex ID: W2153198570