Work

Mps1 Phosphorylation of Dam1 Couples Kinetochores to Microtubule Plus Ends at Metaphase

Year: 2020

Type: article

Abstract: Duplicated chromosomes are equally segregated to daughter cells by a bipolar mitotic spindle during cell division. By metaphase, sister chromatids are coupled to microtubule (MT) plus ends from opposite poles of the bipolar spindle via kinetochores. Here we describe a phosphorylation event that promotes the coupling of kinetochores to microtubule plus ends.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/fnev-4658

Authors: Yates, John R., Bloom, Kerry, Shimogawa, Michelle M., Ess, Michael, Niessen, Sherry, Ruse, Cristian, Molk, Jeffrey N., Muller, Eric G.D., Davis, Trisha N., Odde, David J., Graczyk, Beth, Gardner, Melissa K., Francis, Susan E., White, Erin A.

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of General Medical Sciences, National Center for Research Resources

Awards: G3002317336, G348359138, G3957481211, G4098135243, Training in Cellular and Molecular Biology, Modeling microtubule dynamics in mitosis, Structure and Function of a Eukaryotic Centromere, G7804582509, CAREER: Microtubule Severing Mechanisms

OpenAlex ID: W4298360327

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