Discovery and refinement of loci associated with lipid levels
Year: 2013
Type: article
Study design: Observational Study
Source: Nature Genetics
DOI: 10.1038/ng.2797
Authors: Cristen J Willer, Ellen M Schmidt, Sebanti Sengupta, Jin Chen, Jennifer L Bragg-Gresham, Anne U Jackson, Carlo Sidore, Tanya M Teslovich, Michael Boehnke, Gonçalo R Abecasis, Gina M Peloso, L Adrienne Cupples, Ron Do, Richa Saxena, Sekar Kathiresan, Tõnu Esko, Pierre Fontanillas, Cameron D Palmer, Sailaja Vedantam, Joel N Hirschhorn, Stefan Gustafsson, Andrea Ganna, Ci Song, Agneta Siegbahn, Erik Ingelsson, Stavroula Kanoni, Deepti Gurdasani, Inês Barroso, Theodore Papamarkou, Cristina Pomilla, Kathleen Stirrups, Nicholas Wainwright, Elizabeth H Young, Samuli Ripatti, Manjinder S Sandhu, Panos Deloukas, Patrik K E Magnusson, Nancy L Pedersen, Martin L Buchkovich, Ying Wu, Karen L Mohlke, Samia Mora, Paul M Ridker, Daniel I Chasman, Jacques S Beckmann, Hsing-Yi Chang, Ayşe Demirkan, Aaron Isaacs, Cornelia M van Duijn, Heleen M Den Hertog, Evita G Van den Herik, Peter J Koudstaal, Louise A Donnelly, Alex S F Doney, Andrew D Morris, Colin N A Palmer, Georg B Ehret, François Mach, Aravinda Chakravarti, Krista Fischer, Evelin Mihailov, Markus Perola, Andres Metspalu, Mary F Feitosa, Ingrid B Borecki, Teresa Ferreira, Cecilia M Lindgren, Mark I McCarthy, Ross M Fraser, Jennifer L Bolton, Igor Rudan, Sarah H Wild, James F Wilson, Harry Campbell, Jackie F Price, Daniel F Freitag, John Danesh, Danish Saleheen, Kauko Heikkilä, Jaakko Kaprio, Elina Hyppönen, Chris Power, Åsa Johansson, Ulf Gyllensten, Lars Wallentin, Toby Johnson, Patricia B Munroe, Marika Kaakinen, Marjo-Riitta Järvelin, Paul Elliott, Johannes Kettunen, Ida Surakka, Aarno Palotie, Kaisa Silander, Marcus E Kleber, Winfried März, Xiaohui Li, Eric Kim, Jerome I Rotter, Jian'an Luan, Claudia Langenberg, Ruth J F Loos, Ken K Ong, Jing Hua Zhao, Nicholas J Wareham, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Massimo Mangino, Tim D Spector, May E Montasser, Jeffrey R O'Connell, Braxton D Mitchell, Alan R Shuldiner, Martina Müller-Nurasyid, Ann-Kristin Petersen, Christian Gieger, Ilja M Nolte, Serena Sanna, Susan K Service, Nelson B Freimer, Sonia Shah, Meena Kumari, Aroon Hingorani, Mika Kivimaki, Dmitry Shungin, Paul W Franks, Rona J Strawbridge, Anders Hamsten, Toshiko Tanaka, Luigi Ferrucci, Gudmar Thorleifsson, Hilma Holm, Kari Stefansson, Unnur Thorsteinsdottir, Benjamin F Voight, Kelly A Volcik, Eric Boerwinkle, Lindsay L Waite, Devin Absher, Andrew Wong, Diana Kuh, Weihua Zhang, John C Chambers, Jaspal S Kooner, Gershim Asiki, Pontiano Kaleebu, Rebecca N Nsubuga, Janet Seeley, Latonya F Been, Martha L Gravito, Dharambir K Sanghera, Lori L Bonnycastle, Narisu Narisu, Amy J Swift, Francis S Collins, Paolo Brambilla, Mary S Burnett, Stephen E Epstein, Giancarlo Cesana, Maria Dimitriou, George Dedoussis, Angela Döring, Christa Meisinger, Gudmundur Ingi Eyjolfsson, Bruna Gigante, Ulf de Faire, Mark O Goodarzi, Michelle R Jones, Harald Grallert, Thomas Illig, Norman Klopp, Christopher J Groves, Göran Hallmans, Anna-Liisa Hartikainen, Anneli Pouta, Caroline Hayward, Dena Hernandez, Andrew A Hicks, Peter P Pramstaller, Yi-Jen Hung, John J P Kastelein, G Kees Hovingh, Kay-Tee Khaw, Pirjo Komulainen, Timo A Lakka, Rainer Rauramaa, Shih-Yi Lin, Jaana Lindström, Jaakko Tuomilehto, Wendy L McArdle, Gabrielle Müller, Ramaiah Nagaraja, Tuomo V M Nieminen, Isleifur Olafsson, Daniel J Rader, Muredach P Reilly, Fernando Rivadeneira, Andre G Uitterlinden, Albert Hofman, Aimo Ruokonen, Nilesh Samani, Hubert Scharnagl, Alena Stancáková, Laurence Tiret, L Joost van Pelt, Cisca Wijmenga, Bruce H R Wolffenbuttel, Gonneke Willemsen, Dorret I Boomsma, Tom Wilsgaard, Inger Njølstad, Linda S Adair, Dominique Arveiler, Themistocles L Assimes, Thomas Quertermous, Stefania Bandinelli, Franklyn Bennett, Murielle Bochud, Pascal Bovet, Bernhard O Boehm, Stefan R Bornstein, Peter E H Schwarz, Michel Burnier, Yii-Der Ida Chen, Richard S Cooper, Bamidele O Tayo, Alan B Feranil, Jean Ferrières, Leif C Groop, Vilmundur Gudnason, Tamara B Harris, Chao Agnes Hsiung, Steve E Humphries, Steven C Hunt, Kristian Hveem, Carlos Iribarren, Antti Jula, Mika Kähönen, Antero Kesäniemi, Ronald M Krauss, Johanna Kuusisto, Markku Laakso, Kirsten O Kyvik, Lars Lind, Nicholas G Martin, John B Whitfield, Colin A McKenzie, Pierre Meneton, Leena Moilanen, Bruce M Psaty, Veikko Salomaa, Jouko Saramies, Wayne H-H Sheu, David P Strachan, Elena Tremoli, Matti Uusitupa, Peter Vollenweider, Jose M Ordovas, Stephen S Rich
Institutions: University of Michigan, Michigan Medicine, Broad Institute, Boston University, Massachusetts General Hospital, Uppsala University, Science for Life Laboratory, Wellcome Sanger Institute, University of Sassari, Karolinska Institutet, Institute of Genetic and Biomedical Research, University of North Carolina at Chapel Hill, Brigham and Women's Hospital, Harvard University, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Framingham Heart Study, National Health Research Institutes, Erasmus MC, University of Tartu, University of Dundee, Ninewells Hospital, Boston Children's Hospital, Johns Hopkins University, University Hospital of Geneva, Washington University in St. Louis, Centre for Human Genetics, University of Oxford, University of Edinburgh, University of Cambridge, University of Helsinki, National Institute for Health and Care Research, Addenbrooke's Hospital, NIHR Cambridge Biomedical Research Centre, University College London, Centre for Medical Systems Biology, Queen Mary University of London, William Harvey Research Institute, University of Oulu, Finnish Institute for Health and Welfare, Institute for Molecular Medicine Finland, Universität Ulm, Heidelberg University, University Hospital Ulm, Medizinische Fakultät Mannheim, Cedars-Sinai Medical Center, MRC Epidemiology Unit, Tampere University, Fimlab (Finland), University of Tampere, King's College London, University of Maryland, Baltimore, Helmholtz Munich, Ludwig-Maximilians-Universität München, University Medical Center Groningen, University of Groningen, University of California, Los Angeles, Lund University, Umeå University, Karolinska University Hospital, National Institutes of Health, deCODE Genetics (Iceland), University of Pennsylvania, The University of Texas Health Science Center at Houston, HudsonAlpha Institute for Biotechnology, MRC Unit for Lifelong Health and Ageing, Ealing Hospital, Imperial College London, Oxford Centre for Diabetes, Endocrinology and Metabolism, MRC/UVRI & LSHTM Uganda Research Unit, Uganda Virus Research Institute, University of Oklahoma Health Sciences Center, National Human Genome Research Institute, University of Milano-Bicocca, MedStar Health Research Institute, Harokopio University of Athens, Center for Non-Communicable Diseases, Oulu University Hospital, Western General Hospital, Institute of Genetics and Cancer, MRC Human Genetics Unit, National Institute on Aging, Eurac Research, University of Lübeck, Helsinki University Hospital, Tri-Service General Hospital, National Defense Medical Center, Medizinische Hochschule Hannover, Medical University of Graz, Synlab (Germany), Amsterdam UMC Location University of Amsterdam, Icahn School of Medicine at Mount Sinai, Taichung Veterans General Hospital, National Yang Ming University, University of Bristol, United States Department of Veterans Affairs, Baltimore VA Medical Center, Technische Universität Dresden, Päijät-Hämeen Keskussairaala, National University Hospital of Iceland, Netherlands Consortium for Healthy Ageing, University of Leicester, Glenfield Hospital, NIHR Leicester Cardiovascular Biomedical Research Unit, University of East Anglia, University of Iceland, University of Eastern Finland, Kuopio University Hospital, Inserm, Université Pierre-et-Marie-Curie, Lifelines, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Vrije Universiteit Amsterdam, UiT The Arctic University of Norway, Université de Strasbourg, Stanford Medicine, Stanford University, Azienda Sanitaria di Firenze, University of the West Indies, Institute of Social and Preventive Medicine, Nanyang Technological University, University Hospital Carl Gustav Carus, Ministry of Health, Loyola University Medical Center, Loyola University Chicago, Loyola Medicine, University of San Carlos, Hôpital Rangueil, Université de Toulouse, Icelandic Heart Association, Ospedale di Bolzano, University of Utah, Norwegian University of Science and Technology, Kaiser Permanente, Universität für Weiterbildung Krems, King Abdulaziz University, Hospital Universitario La Paz, University of Southern Denmark, Odense University Hospital, QIMR Berghofer Medical Research Institute, Centre de Recherche des Cordeliers, Group Health Cooperative, Kaiser Permanente Washington Health Research Institute, University of Washington, German Center for Diabetes Research, Paul Langerhans Institute Dresden, South Karelia Central Hospital, St George's, University of London, University of Milan, Centro Cardiologico Monzino, Madrid Institute for Advanced Studies, Tufts University, Spanish National Centre for Cardiovascular Research, Jean Mayer Human Nutrition Research Center on Aging, IMDEA Food, University of Virginia
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: Wellcome Trust, National Institute for Health and Care Research, British Heart Foundation, National Institutes of Health, Medical Research Council, Economic and Social Research Council, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: Genetic Variants Associated with HDL and LDL Cholesterol, and Triglyceride Levels, NIHR Senior Investigator Award, G1896713975, Targeted Genetic Analysis of T2D and Quantitative Traits, Genome-wide Association Scan to Identify Risk Genes for Type 2 Diabetes in Asian, Genome-wide association study of HDL: linking genetic loci for HDL to risk of coronary artery disease, Determinants of healthy ageing in the Whitehall II study, UCLA Clinical and Translational Science Institute, RENEWAL: Dissecting the molecular genetic architecture of plasma lipid traits: identifying functional changes and their use in determining coronary heart disease causality, G4211044638, NIHR Senior Investigator Award, Pharmacogenomics and Risk of Cardiovascular Disease, NIHR Senior Investigator Award, G5517677352, Wellcome Trust - Cambridge Centre for Global Health Research, CHARGE consortium: omics discovery for CVD and aging phenotypes, G6957823285, Understanding the genetic basis of common human diseases: core funding for the Wellcome Trust Centre for Human Genetics., G7129414704, G7374949320, RENEWAL: Systematic approaches to the evaluation of emerging coronary risk markers. Large-scale epidemiological analyses of existing data and stored biological samples, University of Michigan Training Program in Genomic Science, Michigan Diabetes Research Center (MDRC), Genetic epidemiology of rare and regulatory variants for metabolic traits, Diabetes Research Center (DRC), Using genetics to discover mechanisms of abdominal aortic aneurysm
OpenAlex ID: W2153118028