Work

Sequential CCR5-Tropic HIV-1 Reactivation from Distinct Cellular Reservoirs following Perturbation of Elite Control

Year: 2020

Type: article

Abstract: HIV Elite Controllers may reveal insights into virus persistence given they harbour small reservoir sizes, akin to HIV non-controllers treated early with combination antiretroviral therapy. Both groups of patients represent the most promising candidates for interventions aimed at sustained remission or ‘cure’. Analytic treatment interruption (ATI) in the latter group leads to stochastic rebound of virus, though it is unclear whether loss of elite control is also associated with similar rebound characteristics.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/g0fx-0j35

Authors: Maldarelli, Frank, Gupta, Ravindra K., Watters, Sarah A., Mlcochova, Petra, Goonetilleke, Nilu, Pillay, Deenan

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, University College London