Year: 2007
Type: article
Abstract: Skin is a non-classical target for oestrogens. Despite evidence showing that oestrogen receptors (ER) are expressed in skin, there are still extensive gaps in our understanding of how oestrogens exert their action in non-reproductive tissues. Oestrogen-related receptor-alpha (ERRalpha), orphan member of the nuclear receptor superfamily, shows a strong sequence homology with ERalpha but it does not bind oestradiol. Here, for the first time, we demonstrate ERRalpha expression in the epidermis of adult human skin. ERRalpha mRNA was detected in the epidermis of eight female donors using reverse transcriptase polymerase chain reaction. The presence of the protein was confirmed using western blotting and immunohistochemistry on 5 and 11 adult human skins, respectively. This study shows that ERRalpha is expressed in human epidermis and could intervene in a potentially new oestrogen signalling pathway in the skin.
Source: Experimental Dermatology
Authors: Elodie Bertil, Marie‐Alexandrine Bolzinger, Valérie André, Patricia Rousselle, Odile Damour
Institutions: Lyon 1 Université, Centre National de la Recherche Scientifique, Université de Lyon, Institut de Biologie et de Chimie des Protéines, Microbiologie moléculaire et biochimie structurale, Hospices Civils de Lyon, Laboratoire d'Automatique, de Génie des Procédés et de Génie Pharmaceutique
Language: English
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2122545049