Year: 1984
Type: article
Abstract: A method is given for determining the probabilities that genes are identical by descent, at a locus linked to a marker where phenotypic data are available. For tight linkage, such conditional probabilities of identity may differ very much from unconditional ones ; they depend on the dominance relationships between alleles at the marker locus, and on the allelic frequencies. Applications discussed refer to the calculation of general two-locus descent measures, to the validation of pedigrees from polymorphism analysis, and to the statistical detection of an association between a quantitative trait and a marked region of the genome.
Source: HAL
Institution: Laboratoire de Génétique Cellulaire
Language: French
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4298427671