Work

Prospects for Treatment of Latent HIV

Year: 2012

Type: review

Abstract: Recent advances in antiretroviral therapy (ART) have drastically improved the quality of life for people with HIV infection. However, owing to the persistence of latent HIV in the presence of therapy, patients must remain on therapy indefinitely. Currently, the solution to the HIV pandemic rests on the prevention of new infections and many decades of ART for the steadily expanding number of people infected worldwide. ART is costly, requires ongoing medical care, and can have side effects, thereby preventing its universal availability. Therefore, to escape the ironic burdens of therapy, efforts have begun to develop treatments for latent HIV infection. Current approaches propose either complete eradication of infection or induction of a state of stringent control over viral replication without ART. This review will discuss these strategies in detail and their potential for clinical development.

Source: Clinical Pharmacology & Therapeutics

DOI: 10.1038/clpt.2012.202

Authors: K M Barton, B D Burch, N Soriano-Sarabia, D M Margolis

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Gilead Sciences, National Institute on Drug Abuse