Work

Sources of Variation in Sweat Chloride Measurements in Cystic Fibrosis

Year: 2020

Type: article

Abstract: Rationale: Expanding the use of cystic fibrosis transmembrane conductance regulator (CFTR) potentiators and correctors for the treatment of cystic fibrosis (CF) requires precise and accurate biomarkers. Sweat chloride concentration provides an in vivo assessment of CFTR function, but it is unknown the degree to which CFTR mutations account for sweat chloride variation.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/7g6r-x003

Authors: Knowles, Michael R., Corvol, Harriet, Sosnay, Patrick R., Pace, Rhonda G., Cutting, Garry R., McGready, John, Blackman, Scott M., Rommens, Johanna M., Boelle, Pierre-Yves, Collaco, Joseph M., Strug, Lisa J., Raraigh, Karen S.

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Cystic Fibrosis Foundation, Case Western Reserve University, Cystic Fibrosis Canada, National Institutes of Health, Canadian Institutes of Health Research, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: G3161894284, Molecular Genetics of Cystic Fibrosis

OpenAlex ID: W4298843177

FWCI:

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