Single-nucleotide polymorphisms at five loci are associated with C-reactive protein levels in a cohort of Filipino young adults
Year: 2011
Type: article
Study design: Observational Study
Abstract: C-reactive protein (CRP) is a component of nonspecific immune defense and is a reliable marker of low-grade inflammation involved in obesity, type 2 diabetes and cardiovascular disease. Genome-wide association studies in middle-aged and elderly populations, predominantly of European descent, demonstrated associations of CRP levels with single-nucleotide polymorphisms (SNPs) at several loci. To examine whether the variants identified are replicated in Filipino young adults, we applied Tobit regression models to study the association of plasma CRP with 12 SNPs at seven loci in a cohort of 1691 Filipino young adults (aged 21.5±0.3 years) from the Cebu Longitudinal Health and Nutrition Survey. SNPs in or near CRP (P=3.2 × 10(-11)), HNF1A, IL6R, APOE-APOC1 and LEPR showed significant associations (P<0.05) and together explained 4.8% of the total variation in CRP. Modest interactions were observed between LEPR-rs1892534 and waist circumference (uncorrected P(interaction)=0.020) and between APOE-rs769449 and pathogen exposure (uncorrected P(interaction)=0.0073) in models predicting CRP. Our results demonstrated that variants in several loci are significantly associated with plasma CRP in Filipino young adults, suggesting shared genetic influences on circulating CRP across populations and age groups.
Source: Journal of Human Genetics
DOI: 10.1038/jhg.2011.106
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, Fogarty International Center, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Carolina Population Center, G1789099407, Genetic Epidemiology of Body Mass Index, Adiposity and Weight Gain, G1968135291, G227387708, G2553430561, G3253097015, G3897472563, G6206675870, G633297803, An Interdisciplinary Strategy for Obesity (RMI), Obesity development and CVD risk factor clustering in Filipino women & offspring, Effect of Health on Education &Work in Filipino Youth, G9000039219, G9000131094, G9000281921, UNC Center for Environmental Health and Susceptibility, Nutrition Obesity Research Center (NORC)
OpenAlex ID: W2119554251