Alcohol Consumption and the Risk of Colorectal Cancer for Mismatch Repair Gene Mutation Carriers
Year: 2016
Type: article
Study design: Observational Study
Abstract: Background: People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive. Methods: 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between alcohol consumption and colorectal cancer. Results: Colorectal cancer was diagnosed in 769 carriers (40%) at a mean (SD) age of 42.6 (10.3) years. Compared with abstention, ethanol consumption from any alcoholic beverage up to 14 g/day and >28 g/day was associated with increased colorectal cancer risk (HR, 1.50; 95% CI, 1.09–2.07 and 1.69; 95% CI, 1.07–2.65, respectively; Ptrend = 0.05), and colon cancer risk (HR, 1.78; 95% CI, 1.27–2.49 and 1.94; 95% CI, 1.19–3.18, respectively; Ptrend = 0.02). However, there was no clear evidence for an association with rectal cancer risk. Also, there was no evidence for associations between consumption of individual alcoholic beverage types (beer, wine, spirits) and colorectal, colon, or rectal cancer risk. Conclusions: Our data suggest that alcohol consumption, particularly more than 28 g/day of ethanol (∼2 standard drinks of alcohol in the United States), is associated with increased colorectal cancer risk for MMR gene mutation carriers. Impact: Although these data suggested that alcohol consumption in MMR carriers was associated with increased colorectal cancer risk, there was no evidence of a dose-response, and not all types of alcohol consumption were associated with increased risk. Cancer Epidemiol Biomarkers Prev; 26(3); 366–75. ©2016 AACR.
Authors: S. Ghazaleh Dashti, Daniel D. Buchanan, Harindra Jayasekara, Driss Ait Ouakrim, Mark Clendenning, Christophe Rosty, Ingrid M. Winship, Finlay A. Macrae, Graham G. Giles, Susan Parry, Graham Casey, Robert W. Haile, Steven Gallinger, Loïc Le Marchand, Stephen N. Thibodeau, Noralane M. Lindor, Polly A. Newcomb, John D. Potter, John A. Baron, John L. Hopper, Mark A. Jenkins, Aung Ko Win
Institutions: The University of Melbourne, Cancer Council Victoria, The University of Queensland, The Royal Melbourne Hospital, University of Southern California, USC Norris Comprehensive Cancer Center, Stanford Medicine, Stanford Cancer Institute, Stanford University, Mount Sinai Hospital, University of Toronto, Lunenfeld-Tanenbaum Research Institute, University of Hawaii Cancer Center, Mayo Clinic, Mayo Clinic in Arizona, University of Washington, Fred Hutch Cancer Center, Massey University, University of North Carolina at Chapel Hill, Seoul National University
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1472229785, G1474361505, USC Consortium:Colorectal Cancer Family Registry, G1684996355, G2087751801, The Colon Cancer Family Registry: USC Consortium, G2201668368, G2238803135, G2324611989, SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, AUSTRALASIAN C0L0RECTAL CANCER FAMILY STUDY, SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS (SEER) PROGRAM., Colon Cancer Family Registry Cohort, G2639781304, The Colon Cancer Family Registry: Hawaii, G3014186981, G314519557, G3161224617, G3195794184, G3205575695, G322677814, G3345109227, G362354808, Seattle Colorectal Cancer Family Registry (CFR), G3913695697, G391480630, WS No. 12 Patterns of Care DX Year 2008, G3947049975, Hawaii Colorectal Cancer Family Registry, Ontario Registry for Studies of Familial Colon Cancer, G4467426518, G4539328454, G480705112, Familial Colorectal Neoplasia Collaborative Group, G520127953, G5269726731, G5333917095, G5570217171, The Colon Cancer Family Registry: Australasia, G5786682175, Bowel cancer prevention, The Colon Cancer Family Registry: Seattle, G6034862151, G6074916046, G6304431425, The Familial Colorectal Neoplasia Collaborative Group, The Colon Cancer Family Registry: Ontario, G6671163260, G667355291, G6918134795, G731770265, G7555119139, G804866679, G8550955980, AUSTRALASIAN COLORECTAL CANCER FAMILY REGISTRY, Mayo Clinic Comprehensive Cancer Center Support Grant, University of Hawaii Cancer Center CCSG, G980164052
OpenAlex ID: W2547189539