Loss of Heterozygosity at the CYP2D6 Locus in Breast Cancer: Implications for Germline Pharmacogenetic Studies
Year: 2021
Type: article
Abstract: Controversy exists regarding the impact of CYP2D6 genotype on tamoxifen responsiveness. We examined loss of heterozygosity (LOH) at the CYP2D6 locus and determined its impact on genotyping error when tumor tissue is used as a DNA source.
DOI: 10.17615/bjr6-0649
Authors: Kalari, Krishna R., Cox, Nancy J., Ratain, Mark J., Stephens, Philip J., Miller, Vincent A., Nakamura, Yusuke, Chen, David, Perou, Charles M., Sun, James X., Safgren, Stephanie L., Ross, Jeffrey S., Burgues, Octavio, Ames, Matthew M., Brauch, Hiltrud B., Gomez, Henry L., Ingle, James N., Goetz, Matthew P., Suman, Vera J., Yelensky, Roman, Silva, Grace O., Gonzalez-Angulo, Ana M., Kuffel, Mary J.
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Pharmacology
Domain: Life Sciences
Open Access status: green
Awards: G424082930, G4390033113
OpenAlex ID: W4299290636