Work

Novel Diamidines with Activity against Babesia divergens In Vitro and Babesia microti In Vivo

Year: 2011

Type: article

Abstract: Dicationic diamidines, such as diminazene and pentamidine, are well-studied chemotherapeutic agents with significant activity against parasitic diseases. The in vitro activities of novel diamidine compounds against the Babesia divergens strains 1903B and 4201 were investigated. The most potent compound, a diphenyl furan, had a 50% inhibitory concentration (IC(50)) of 1.5 ng/ml. In a murine model, several test compounds were effective enough to cure mice infected with Babesia microti at a dose of 12.5 and/or 25 mg/kg of body weight given by the subcutaneous route for 4 days. The best antibabesial properties were exhibited by terphenyls, benzimidazoles, diphenyl furans, pentamidine, and pentamidine analogues.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.01482-10

Authors: Angela Nehrbass-Stuedli, David Boykin, Richard R. Tidwell, Reto Brun

Institutions: Swiss Tropical and Public Health Institute, Georgia State University, University of North Carolina at Chapel Hill, University of Basel

Language: English

Topic: Vector-borne infectious diseases

Subfield: Parasitology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2136320743

FWCI: 1.131

Cites: 31

Cited by: 15

Related to: 10