Work

Snapshots: Chromatin control of viral infection

Year: 2021

Type: article

Abstract: Like their cellular host counterparts, many invading viral pathogens must contend with, modulate, and utilize the host cell’s chromatin machinery to promote efficient lytic infection or control persistent-latent states. While not intended to be comprehensive, this review represents a compilation of conceptual snapshots of the dynamic interplay of viruses with the chromatin environment. Contributions focus on chromatin dynamics during infection, viral circumvention of cellular chromatin repression, chromatin organization of large DNA viruses, tethering and persistence, viral interactions with cellular chromatin modulation machinery, and control of viral latency-reactivation cycles.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/y0kx-xm67

Authors: Lieberman, Paul M., Jung, Jae U., Nevels, Michael, Nieto, Amelia, Morris, Kevin V., McBride, Alison A., Parks, Robin J., Kristie, Thomas M., Ott, Melanie, Knipe, David M., Margolis, David

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Deutsche Forschungsgemeinschaft, National Institutes of Health, Canadian Institutes of Health Research, Instituto de Salud Carlos III, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Institute of Dental and Craniofacial Research, NHLBI Division of Intramural Research

Awards: G1095549115, Genetics of Herpesvirus Transformation, G7038704564, Epigenetic Regulation of Epstein-Barr Virus

OpenAlex ID: W4299526698

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