Work

Finding genes and variants for lipid levels after genome-wide association analysis

Year: 2020

Type: article

Abstract: We review the main findings from genome-wide association studies (GWAS) for levels of HDL-cholesterol, LDL-cholesterol and triglycerides, including approaches to identify the functional variant(s) or gene(s). We discuss study design and challenges related to whole genome or exome sequencing to identify novel genes and variants.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/1nrs-zs32

Authors: Willer, Cristen J., Mohlke, Karen L.

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute

Award: Using genetics to discover mechanisms of abdominal aortic aneurysm