Work

Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?

Year: 2012

Type: article

Abstract: The Nonhomologous end joining pathway is essential for efficient repair of chromosome double strand breaks. This pathway consequently plays a key role in cellular resistance to break-inducing exogenous agents, as well as in the developmentally-programmed recombinations that are required for adaptive immunity. Chromosome breaks often have complex or "dirty" end structures that can interfere with the critical ligation step in this pathway; we review here how Nonhomologous end joining resolves such breaks.

Source: Genome Integrity

DOI: 10.1186/2041-9414-3-10

Authors: Natasha Tiffany Strande, Crystal Ann Waters, Dale A Ramsden

Institutions: University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: DNA Polymerases in Nonhomologous End Joining, Resolution of Complex Breaks by Nonhomologous End Joining, NRSA in Genetics