Latency reversal and viral clearance to cure HIV-1
Year: 2016
Type: review
Abstract: Research toward a cure for human immunodeficiency virus type 1 (HIV-1) infection has joined prevention and treatment efforts in the global public health agenda. A major approach to HIV eradication envisions antiretroviral suppression, paired with targeted therapies to enforce the expression of viral antigen from quiescent HIV-1 genomes, and immunotherapies to clear latent infection. These strategies are targeted to lead to viral eradication--a cure for AIDS. Paired testing of latency reversal and clearance strategies has begun, but additional obstacles to HIV eradication may emerge. Nevertheless, there is reason for optimism that advances in long-acting antiretroviral therapy and HIV prevention strategies will contribute to efforts in HIV cure research and that the implementation of these efforts will synergize to markedly blunt the effect of the HIV pandemic on society.
Source: Science
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: Role of Myeloid Cells in HIV latency in the Periphery and the CNS, Plug & Purge: In Vivo Targeting of Active HIV Reservoirs That Persist Despite ART, Collaboratory of AIDS Researchers for Eradication (CARE), Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, G654751394, G8144583500, Martin Delaney Collaboratory to Eradicate HIV-1 Infection, G9000070645, The University of North Carolina Center for AIDS Research, G994363756
OpenAlex ID: W2489079158