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Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A

Year: 2020
Type: article
Study design: Case Report
Abstract: KSHV inflammatory cytokine syndrome (KICS) is a newly described condition characterized by systemic illness as a result of systemic, lytic KSHV infection. We used Illumina sequencing to establish the DNA vironome of blood from such a patient. It identified concurrent high-level viremia of human herpesvirus (HHV) 8 and 6a. The HHV8 plasma viral load was 5,300,000 copies/ml, which is the highest reported to date; this despite <5 skin lesions and no HHV8 associated lymphoma. This is the first report of systemic HHV6a/KSHV co-infection in a patient. It is the first whole genome KSHV sequence to be determined directly from patient plasma rather than cultured or biopsied tumor material. This case supports KICS as a new clinical entity associated with KSHV.
DOI: 10.17615/465v-k973
Authors: van der Horst, Charles, Dittmer, Dirk P., Moll, Stephan, Damania, Blossom, Lucas, Amy, Yang, Dongmei, Malouf, Nadia, Moylan, Vincent, Sin, Sang-Hoon, Tamburro, Kristen M., Poisson, Jessica, Fedoriw, Yuri, Roy, Debasmita
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: green
Funders: Howard Hughes Medical Institute, National Institutes of Health, Center for AIDS Research, University of Washington, University of North Carolina at Chapel Hill, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Dental and Craniofacial Research
OpenAlex ID: W4299709045
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