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Physiologically Based Pharmacokinetic (PBPK) Modeling of Interstrain Variability in Trichloroethylene Metabolism in the Mouse

Year: 2020
Type: article
Abstract: Background: Quantitative estimation of toxicokinetic variability in the human population is a persistent challenge in risk assessment of environmental chemicals. Traditionally, interindividual differences in the population are accounted for by default assumptions or, in rare cases, are based on human toxicokinetic data.
DOI: 10.17615/d9wp-7v22
Authors: Campbell, Jerry L., Chiu, Weihsueh A., Guyton, Kathryn Z., Rusyn, Ivan, Clewell, Harvey J., Wright, Fred A., Zhou, Yi-Hui
Language: English
Subfield: Pharmacology
Open Access status: green
Awards: G9000005264, G9000008043, G9000076506, G9000099626, G9000257293, G9000294923
OpenAlex ID: W4299724673
FWCI:
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