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A Role for Cdc2- and PP2A-Mediated Regulation of Emi2 in the Maintenance of CSF Arrest

Year: 2020

Type: article

Abstract: Vertebrate oocytes are arrested in metaphase II of meiosis prior to fertilization by cytostatic factor (CSF). CSF enforces a cell cycle arrest by inhibiting the anaphase promoting complex (APC), an E3 ubiquitin ligase that targets Cyclin B for degradation. Although Cyclin B synthesis is ongoing during CSF arrest, constant Cyclin B levels are maintained. To achieve this, oocytes allow continuous slow Cyclin B degradation, without eliminating the bulk of Cyclin B, which would induce release from CSF arrest. However, the mechanism that controls this continuous degradation is not understood.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/mpp1-2d35

Authors: Tung, Jeffrey J., Jackson, Peter K., Margolis, Seth S., Kornbluth, Sally, Guo, Yanxiang, Araki, Marito, Freel, Christopher D., Yamano, Hiroyuki, Wu, Qiju, Asano, Maki, Tang, Wanli, Perry, Jennifer A., Yamada, Ayumi, Wang, Michael Z.

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: University of North Carolina at Chapel Hill

OpenAlex ID: W4299732162

FWCI:

Cites:

Cited by: 3

Related to: 10