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Aggression and Quantitative MRI Measures of Caudate in Patients With Chronic Schizophrenia or Schizoaffective Disorder

Year: 2020

Type: article

Abstract: Caudate dysfunction is implicated in schizophrenia. However, little is known about the relationship between aggression and caudate volumes. Forty-nine patients received magnetic resonance imaging scanning in a double-blind treatment study in which aggression was measured. Caudate volumes were computed using a semiautomated method. The authors measured aggression with the Overt Aggression Scale and the Positive and Negative Syndrome Scale. Larger caudate volumes were associated with greater levels of aggression. The relationship between aggression and caudate volumes may be related to the iatrogenic effects of long-term treatment with typical anti-psychotic agents or to a direct effect of schizophrenic processes on the caudate.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/va0n-h090

Authors: Lieberman, Jeffrey A., Gerig, Guido, Bilder, Robert M., Lindenmayer, Jean-Pierre, Citrome, Leslie L., Chakos, Miranda, Sheitman, Brain, Blocher, Joseph, Volavka, Jan, Hoptman, Matthew J., Czobor, Pál

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Eli Lilly and Company, Novartis Pharmaceuticals Corporation, National Alliance for Research on Schizophrenia and Depression, National Institute of Mental Health

OpenAlex ID: W4299860692

FWCI:

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