Work

Ras-Related Small GTPases RalA and RalB Regulate Cellular Survival After Ionizing Radiation

Year: 2020

Type: article

Abstract: Oncogenic activation of Ras renders cancer cells resistant to ionizing radiation (IR), but the mechanisms have not been fully characterized. The Ras-like small GTPases, RalA and RalB, are downstream effectors of Ras function and are critical for both tumor growth and survival. The Ral effector RalBP1/RLIP76 mediates survival of mice after whole body irradiation but the role of the Ral GTPases themselves in response to IR is unknown. We have investigated the role of RalA and RalB in cellular responses to IR.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/bm21-p548

Authors: Martin, Timothy D., Der, Channing J., Cox, Adrienne D., Kidd, Ambrose R., Snider, Jared L., Graboski, Sarah F.

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: University of North Carolina at Chapel Hill

OpenAlex ID: W4299865291