Work

Bioavailable insulin-like growth factor-I as mediator of racial disparity in obesity-relevant breast and colorectal cancer risk among postmenopausal women

Year: 2020

Type: article

Abstract: Bioavailable insulin-like growth factor (IGF)-I interacts with obesity and exogenous estrogen in a racial disparity in obesity-related cancer risk, yet their interconnected pathways are not fully characterized. We investigated whether circulating bioavailable IGF-I acted as a mediator of the racial disparity in obesity-related cancers such as breast and colorectal (CR) cancers and how obesity and estrogen use regulate this relationship.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/c9h6-9g12

Authors: Lane, Dorothy S., Hou, Lifang, Corbie-Smith, Giselle, Jung, Su Yon, Chen, Chu, Barrington, Wendy E., Crandall, Carolyn J., Paek, Min-So, Zhang, Zuo-Feng, Chlebowski, Rowan

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Growth Hormone and Insulin-like Growth Factors

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Reduced inequalities

Open Access status: green

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: G1057152193, G1165142596, G2636451769, G3255761503, G3545534745, G3796112702, G4021838900, G4240450635, G4312823968, G433713863, G4430667546, G4940192625, G5547620395, G5624510383, G614814196, G619791618, G6967911674, G8536616440

OpenAlex ID: W4299915903

FWCI:

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