Work

Association of RGS2 and RGS5 variants with schizophrenia symptom severity

Year: 2020

Type: article

Abstract: Several lines of evidence indicate that Regulator of G Protein Signaling 4 (RGS4) contributes to schizophrenia vulnerability. RGS4 is one of a family of molecules that modulate signaling via G-protein coupled receptors. Five genes encoding members of this family (RGS2, RGS4, RGS5, RGS8 and RGS16) map to chromosome 1q23.3-1q31. Due to overlapping cellular functions and chromosomal proximity, we hypothesized that multiple RGS genes may contribute to schizophrenia severity and treatment responsiveness.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/thd8-5j81

Authors: Skelly, Tara, Lieberman, Jeffrey, Sullivan, Patrick F., Lange, Leslie A., Campbell, Daniel B., Levitt, Pat

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green