A reference panel of 64,976 haplotypes for genotype imputation
Year: 2020
Type: article
Abstract: We describe a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole genome sequence data from 20 studies of predominantly European ancestry. Using this resource leads to accurate genotype imputation at minor allele frequencies as low as 0.1%, a large increase in the number of SNPs tested in association studies and can help to discover and refine causal loci. We describe remote server resources that allow researchers to carry out imputation and phasing consistently and efficiently.
Source: UNC Libraries
DOI: 10.17615/pzea-a952
Authors: Dorr, Marcus, Traglia, Michela, Toniolo, Daniela, Chew, Emily, Cocca, Massimiliano, Wijmenga, Cisca, Dekker, Annelot, Ripatti, Samuli, Myers, Richard M., Wood, Andrew R., Schlessinger, David, Swaroop, Anand, Teumer, Alexander, McCarthy, Shane, Palotie, Aarno, Chen, Sai, Corbin, Laura J., McCarroll, Steven, Zeggini, Eleftheria, Veldink, Jan, Sampson, Matthew G., Breen, Gerome, Tuomilehto, Jaakko, Vincent, John B., Gandin, Ilaria, Van Rheenen, Wouter, Das, Sayantan, Angius, Andrea, McInnis, Melvin, Meitinger, Thomas, Zhang, He, Kretzler, Matthias, Kang, Hyun Min, Walter, Klaudia, De Bakker, Paul I. W., Gilly, Arthur, Spector, Timothy, Min, Josine L., Gasparini, Paolo, Danecek, Petr, Melzer, David, Timpson, Nicholas, Sala, Cinzia, Small, Kerrin, Kretzschmar, Warren, Kwong, Alan, Scott, Laura J., Wilson, James F., Lee, James C., Holmen, Oddgeir L., Stambolian, Dwight, Marchini, Jonathan, Iacono, William, Durbin, Richard, Luo, Yang, Peters, Ulrike, Soranzo, Nicole, Schoenherr, Sebastian, Slagboom, P Eline, Campbell, Harry, Forer, Lukas, Groop, Leif, Mohlke, Karen L., Richards, J Brent, Nickerson, Deborah, Hattersley, Andrew, Anderson, Carl A., Tuke, Marcus, McGue, Matt, Fuchsberger, Christian, Pirastu, Nicola, Vrieze, Scott, Ferrucci, Luigi, Mahajan, Anubha, Harrison, Tabitha, Boehnke, Michael, Cucca, Francesco, Chan, Andrew, Van Duijn, Cornelia M., Swertz, Morris A., Kooperberg, Charles, Mezzavilla, Massimo, Gabriel, Stacey, Sidore, Carlo, Sharp, Kevin, Koskinen, Seppo, Delaneau, Olivier, Altshuler, David, Boomsma, Dorrett, Willer, Cristen, McCarthy, Mark I., Farmaki, Aliki-Eleni, Van Den Berg, Leonard H., Collins, Francis S., Smith, George Davey, Dedoussis, George, Busonero, Fabio, Branham, Kari, Salomaa, Veikko, Levy, Shawn, Pato, Carlos, Volker, Uwe, Barrett, Jeffrey C., Abecasis, Gonçalo, Pato, Michele, Nauck, Matthias, Hveem, Kristian, Gillies, Christopher E., Brummett, Chad M., Fraser, Ross M., Frayling, Timothy
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4300022701