Work

A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation:

Year: 2020

Type: review

Abstract: Drugs that exhibit close margins between therapeutic and toxic blood concentrations are considered to have a narrow therapeutic index (NTI). The Food and Drug Administration has proposed that NTI drugs should have more stringent bioequivalence standards for approval of generic formulations. However, many immunosuppressant drugs do not have a well-defined therapeutic index (TI).

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/762d-0y78

Authors: Guptill, Jeffrey T., Hill, Kevin D., Melloni, Chiara, Gonzalez, Daniel, Zimmerman, Kanecia O., Cohen-Wolkowiez, Michael, Wu, Huali, Ericson, Jessica E.

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Renal Transplantation Outcomes and Treatments

Subfield: Transplantation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4300030955

FWCI:

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