Work

Hijacking the Chromatin Remodeling Machinery: Impact ofSWI/SNFPerturbations in Cancer

Year: 2009

Type: review

Abstract: There is increasing evidence that alterations in chromatin remodeling play a significant role in human disease. The SWI/SNF chromatin remodeling complex family mobilizes nucleosomes and functions as a master regulator of gene expression and chromatin dynamics whose functional specificity is driven by combinatorial assembly of a central ATPase and association with 10 to 12 unique subunits. Although the biochemical consequence of SWI/SNF in model systems has been extensively reviewed, the present article focuses on the evidence linking SWI/SNF perturbations to cancer initiation and tumor progression in human disease.

Source: Cancer Research

DOI: 10.1158/0008-5472.can-09-2166

Authors: Bernard Weissman, Karen E. Knudsen

Institutions: University of North Carolina at Chapel Hill, Thomas Jefferson University, Sidney Kimmel Cancer Center, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Chromatin Remodeling and Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Washington, National Cancer Institute, National Institute of Environmental Health Sciences