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Fat-Specific Protein 27/CIDEC Promotes Development of Alcoholic Steatohepatitis in Mice and Humans

Year: 2020

Type: article

Abstract: Alcoholic steatohepatitis (ASH) is the progressive form of alcoholic liver disease and may lead to cirrhosis and hepatocellular carcinoma. We studied mouse models and human tissues to identify molecules associated with ASH progression, and focused on mouse fat-specific protein 27 (FSP-27)/human cell death-inducing DFF45-like effector C (CIDEC) protein, which is expressed in white adipose tissues and promotes formation of fat droplets.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/gj4w-rb03

Authors: Lu, Jim, Kimura, Shioko, Xu, Ming-Jiang, Odena, Gemma, Tanaka, Naoki, Gonzalez, Frank J., Bataller, Ramon, Pacher, Pal, Cai, Yan, Gao, Bin, Altamirano, José, Bertola, Adeline, Wang, Hua, Matsubara, Tsutomu, Chang, Binxia, Matsusue, Kimihiko, Mukhopadhyay, Partha

Language: English

Topic: Alcohol Consumption and Health Effects

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4300078255

FWCI: 0.823

Cites:

Cited by: 5

Related to: 10