Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Year: 2020
Type: review
Abstract: To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide association studies in 87,802 women of European descent, with replication in up to 14,731 women. In addition to the known loci at LIN28B (P=5.4×10−60) and 9q31.2 (P=2.2×10−33), we identified 30 novel menarche loci (all P<5×10−8) and found suggestive evidence for a further 10 loci (P<1.9×10−6). New loci included four previously associated with BMI (in/near FTO, SEC16B, TRA2B and TMEM18), three in/near other genes implicated in energy homeostasis (BSX, CRTC1, and MCHR2), and three in/near genes implicated in hormonal regulation (INHBA, PCSK2 and RXRG). Ingenuity and MAGENTA pathway analyses identified coenzyme A and fatty acid biosynthesis as biological processes related to menarche timing.
Source: UNC Libraries
DOI: 10.17615/9qtf-tf51
Authors: Magnusson, Patrik K E, Ulivi, Shelia, Byrne, Enda M, Lunetta, Kathryn L, Chasman, Daniel I, He, Chunyan, Franceschini, Nora, Corre, Tanguy, van Wingerden, Sophie H, Esko, Tõnu, Zhao, Jing Hua, McArdle, Patrick F, Cousminer, Diana L, Marongiu, Mara, Koller, Daniel L, Feenstra, Bjarke, Hayward, Caroline, Kutalik, Zoltán, Smith, Albert V, Stolk, Lisette, Smith, Erin N, Mangino, Massimo, Visser, Jenny A, Warrington, Nicole M, Lin, Peng, Sulem, Patrick, Hottenga, Jouke-Jan, Elks, Cathy E, Gudbjartsson, Daniel F, Ingelsson, Erik, Albrecht, Eva, Perry, John R B
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, Juvenile Diabetes Research Foundation International, March of Dimes Foundation, American Heart Association, Amgen, GlaxoSmithKline, Compagnia di San Paolo, Wellcome Trust, Scottish Government, European Commission, University of Bristol, National Research Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Stiftelsen för Strategisk Forskning, Danmarks Grundforskningsfond, Bundesministerium für Bildung und Forschung, Fondazione Cariplo, Erasmus Medisch Centrum, Ministero della Salute, Hjärt-Lungfonden, Vetenskapsrådet, Ministère de l'Education Nationale, de l'Enseignement Superieur et de la Recherche, Augustinus Fonden, Fondation Leenaards, Svenska Läkaresällskapet, Chinese Society of Clinical Oncology, Egmont Fonden, Hjartavernd, Centre for Medical Systems Biology, National Institutes of Health, Canadian Institutes of Health Research, Medical Research Council, Australian Research Council, National Health and Medical Research Council, European Regional Development Fund, Helmholtz Zentrum München, Münchner Zentrum für Gesundheitswissenschaften, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: From modules to models: towards a better understanding of disease through advanced analysis of large-scale data, G1077033501, G1137313802, G118440752, Opening Estonian Genome Project for European Research Area, G1270179341, G136105103, G1477066782, Le temps des événements. Pragmatique de la référence temporelle., G1641692689, G1664136512, G1689944598, Validation and Replication of Genes Associated with Common Human Disease Using Australian Twin Families, G1798569254, ALSPAC: consolidation of a two generation cell line backed resource, for the study of the environment and genetic determinants of health and development from before birth to late puberty., G1924190148, Maximising knowledge from dense SNP (single nucleotide polymorphisms) data using multi-locus analysis, G1975277730, FIELD CENTER FOR CCSP, G2064885621, G215333750, CCSP FIELD CENTER, G2179969359, Cardiovascular diseases and psychiatric disorders in the general population: a prospective follow-up study, G250621538, G2509620945, Understanding genetic and environmental causes of chronic adult disease in early life, G25881238, G2697361861, Heidenhüttli - 25 Jahre archäologische Wüstungsforschung im schweizerischen Alpenraum, G2818913090, G2957143966, G3001543491, Vegetations-und Standortsveränderungen auf von Hochwasser überschlickten Riedflächen, G3081738709, G3164675021, G3227761751, Verbundprojekt Molekulare Mechanismen der Adipositas - Gen Validierung in epidemiologischen Kohorten und Fall-Kontrollstudien (WB2-A) und Funktionelle Studien von adipositasrelevanten Genen (WB3-A), G3349769430, G3367174484, G3398637311, G3444887196, Identification of genetic risk factors for asthma: genome-wide association and the role of epigenetics, G36937976, G374919288, G37846424, G3814398992, G3915381216, An object-based evaluation of the forecast uncertainty of Mediterranean cyclones and their associated surface weather extremes, G395156118, Dietary and Hormonal Determinants of Cancer in Women, COMMUNITY AND COHORT SURVEILLANCE PROGRAM, Genome-wide combined linkage-association scan of multiply phenotyped twin sibships, Pigmentation genes and melanoma risk, 35ème cours de l'AVCP : 'La formation des éléments chimiques', G4122201895, G4178577773, European Network for Genetic-Epidemiological Studies: building a method to dissect complex genetic traits, using essential hypertension as a disease model, G4362647046, G4383452904, Genetics and prediction of complex disease risk, Association Screen of Migraine Candidate Genes, European Network for Genetic and Genomic Epidemiology, The History of Utopian Thinking in 20 th Century Poland, GENETIC FACTORS FOR OSTEOPOROSIS, G4818431986, FIELD CENTER, G528395701, CCSP - FIELD CENTER AND ULTRASOUND READING CENTER, Unlocking the European Union convergence region potential in genetics, Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood, G5502349062, G5568298347, G558986044, G5599442719, Mapping Genes for typical migraine using twin families., G5636245874, G5649857278, G5654214539, COMMUNITY AND COHORT SURVEILLANCE PROGRAMS, G5780067080, G5844522323, G6091493096, G6196377753, G6255202575, G6343431347, « Inter Arma Helvetia » Swiss humanitarian action during the Great War, Asymmetric Catalysis, Genetics of moliness, G67356480, Develop & improve methodology in gene mapping, targetting localisation of genes underlying migraine & other disorders, Quantitative and Molecular Genetic Analysis of Cognition, G6832097205, G6838805842, Uncoupled Research Fellowship, THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195, G6902192277, Training Overparametrized Models with SGD: the Impact of Noise, Genetics of moliness, Mid-Atlantic Nutrition Obesity Research Center, G7028328829, Prospective Studies of Diet and Cancer in Men and Women, G7627314639, G7850585328, G786153652, Geomorphic and climatic controls on riverine carbon export in active landscapes, Short- and long-term impacts of career counseling: Investigation of cognitive and relational components, G793702358, G7962241407, CENTRAL HEMOSTATIS LABORATORY FOR CCSP, Locating genes for elementary and complex cognitive abilities using genetic linkage and association analysis, G8210461904, G8253295407, Franz Overbeck - Werke und Nachlass Bd. 7/2. Autobiographisches. 'Meine Freunde Treitschke, Nietzsche,und Rohde'. Herausgegeben von Barbara von Reibnitz, G8393905554, G8505307412, Biobanking and Biomolecular Resources Research Infrastructure, Statistical Methods and Algorithms for Analysis of High-throughput Genetics and Genomics Platforms, From GWAS loci to blood pressure genes, variants & mechanisms - Renewal, G941997257, G970400076
OpenAlex ID: W4300419588