Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia
Year: 2020
Type: article
Abstract: In Cambodia, where Plasmodium vivax and Plasmodium falciparum are coendemic and intense multimodal malaria-control interventions have reduced malaria incidence, P. vivax malaria has proven relatively resistant to such measures. We performed comparative genomic analyses of 150 P. vivax and P. falciparum isolates to determine whether different evolutionary strategies might underlie this species-specific resilience. Demographic modeling and tests of selection show that, in contrast to P. falciparum, P. vivax has experienced uninterrupted growth and positive selection at multiple loci encoding transcriptional regulators. In particular, a strong selective sweep involving an AP2 transcription factor suggests that P. vivax may use nuanced transcriptional approaches to population maintenance. Better understanding of P. vivax transcriptional regulation may lead to improved tools to achieve elimination.
DOI: 10.17615/eqkb-sq35
Authors: Spring, Michele D., Chuor, Char Meng, Lon, Chanthap, Bailey, Jeffrey A., Ayala, Francisco J., Balasubramanian, Sujata, Meshnick, Steven R., Lanteri, Charlotte A., Brazeau, Nicholas, Lin, Jessica T., Juliano, Jonathan J., Barnett, Eric J., Parobek, Christian M., De Conti, Derrick K., Saunders, David L., Garba, Deen L.
Institution: University of North Carolina at Chapel Hill
Language: English
Topic: Malaria Research and Control
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4300420470