Relationship between hair cortisol concentrations and depressive symptoms in patients with coronary artery disease.
Year: 2010
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Concentrations of cortisol in hair, a novel marker of longer-term cortisol status, were compared in depressed versus nondepressed patients with coronary artery disease (CAD). METHODS: 20 mg hair samples of 3 cm length were collected from 121 patients attending a cardiac rehabilitation program, 34 of whom suffered from depressive symptoms. RESULTS: Controlling for age, gender, coronary artery bypass grafting, history of depression, and time since most recent acute coronary syndrome, cortisol concentrations (P = 0.162) did not predict severity of depression. Younger age (P = 0.003) was a significant predictor of depressive symptoms. Perceived stress was not associated with long-term cortisol concentrations (P = 0.161). CONCLUSIONS: Cortisol concentrations in hair do not predict depressive symptoms in CAD patients attending cardiac rehabilitation.
Source: PubMed Central
Institution: University of Toronto
Language: English
Subfield: Behavioral Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2109699728