Work

Integrin signaling to the actin cytoskeleton

Year: 2019

Type: article

Abstract: Integrin engagement stimulates the activity of numerous signaling molecules, including the Rho family of GTPases, tyrosine phosphatases, cAMP-dependent protein kinase and protein kinase C, and stimulates production of PtdIns(4,5)P2. Integrins promote actin assembly via the recruitment of molecules that directly activate the actin polymerization machinery or physically link it to sites of cell adhesion.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/sgax-4h23

Authors: Wennerberg, Krister, DeMali, Kris A., Burridge, Keith

Institutions: University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Cell Adhesion Molecules Research

Subfield: Immunology and Allergy

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Institutes of Health

Awards: G9000214137, G9000223314