Work

CRISPR/Cas9-mediated Gene Knockout Followed by Negative Selection Leads to a Complete TCR Depletion in orthoCAR19 T Cells

Year: 2022

Type: article

Abstract: CAR19 T cells using (1) CRISPR/Cas9-mediated gene knockout followed by (2) CD3 negative selection.

Source: BIO-PROTOCOL

DOI: 10.21769/bioprotoc.4485

Authors: Qian Zhang, Jingyi Yang, Eric Nigel Ebenezer Anand Manoharan, Alvin Yu, Michael Milone

Institution: University of Pennsylvania

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4300489372

FWCI: 0.207

Cites: 8

Cited by: 7

Related to: 10