Comparison of Biomarkers in Transgenic Alzheimer Rats Using Multi-Shell Diffusion MRI
Year: 2016
Type: book-chapter
Abstract: In this study, we assessed the evolution of diffusion MRI (dMRI) derived markers from different white matter models as progressive neurodegeneration occurs in transgenic Alzheimer rats (TgF344-AD) at 10, 15 and 24 months. We compared biomarkers reconstructed from Diffusion Tensor Imaging (DTI), Neurite Orientation Dispersion and Density Imaging (NODDI) and Mean Apparent Propagator (MAP)-MRI in the hippocampus, cingulate cortex and corpus callosum using multi-shell dMRI. We found that NODDI's dispersion and MAP-MRI's anisotropy markers consistently changed over time, possibly indicating that these measures are sensitive to age-dependent neuronal demise due to amyloid accumulation. Conversely, we found that DTI's mean diffu-sivity, NODDI's isotropic volume fraction and MAP-MRI's restriction-related metrics all followed a two-step progression from 10 to 15 months, and from 15 to 24 months. This two-step pattern might be linked with a neuroinflammatory response that may be occuring prior to, or during microstructural breakdown. Using our approach, we are able to provide for the first time-preliminary and valuable insight on relevant biomarkers that may directly describe the underlying pathophysiology in Alzheimer's disease.
Authors: Fick, Rutger, H.J., Daianu, Madelaine, Pizzolato, Marco, Wassermann, Demian, Jacobs, Russel E., Thompson, Paul M., Town, Terrence, Deriche, Rachid
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4300597379