The Clinical Translation Gap in Child Health Exercise Research: A Call for Disruptive Innovation
Year: 2014
Type: article
Abstract: In children, levels of play, physical activity, and fitness are key indicators of health and disease and closely tied to optimal growth and development. Cardiopulmonary exercise testing (CPET) provides clinicians with biomarkers of disease and effectiveness of therapy, and researchers with novel insights into fundamental biological mechanisms reflecting an integrated physiological response that is hidden when the child is at rest. Yet the growth of clinical trials utilizing CPET in pediatrics remains stunted despite the current emphasis on preventative medicine and the growing recognition that therapies used in children should be clinically tested in children. There exists a translational gap between basic discovery and clinical application in this essential component of child health. To address this gap, the NIH provided funding through the Clinical and Translational Science Award (CTSA) program to convene a panel of experts. This report summarizes our major findings and outlines next steps necessary to enhance child health exercise medicine translational research. We present specific plans to bolster data interoperability, improve child health CPET reference values, stimulate formal training in exercise medicine for child health care professionals, and outline innovative approaches through which exercise medicine can become more accessible and advance therapeutics across the broad spectrum of child health.
DOI: 10.1111/cts.12194
Authors: Naveen Ashish, Marcas M. Bamman, Frank J. Cerny, Dan M. Cooper, Pierre D'Hemecourt, Joey C. Eisenmann, Dawn Ericson, John Fahey, Bareket Falk, Davera Gabriel, Michael G. Kahn, Han C.G. Kemper, Szu-Yun Leu, Robert I. Liem, Robert McMurray, Patricia A. Nixon, J. Tod Olin, Paolo T. Pianosi, Mary Purucker, Shlomit Radom-Aizik, Amy Taylor
Institutions: University of Southern California, University of Alabama at Birmingham, Women & Children's Hospital of Buffalo, University at Buffalo, State University of New York, University of California, Irvine, Boston Children's Hospital, Michigan State University, Yale University, Brock University, University of California, Davis, University of Colorado Anschutz, University of Colorado Denver, Amsterdam Public Health, Amsterdam UMC Location Vrije Universiteit Amsterdam, Northwestern University, University of North Carolina at Chapel Hill, Wake Forest University, National Jewish Health, Mayo Clinic, National Institutes of Health, National Center for Advancing Translational Sciences, Children's Hospital Colorado
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Georgia Clinical and Translational Science Alliance, National Institutes of Health, University of California, Irvine, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
OpenAlex ID: W1634465826