Work

Increased Consumption but Not Operant Self-administration of Ethanol in Mice Lacking the RIIbeta Subunit of Protein Kinase A

Year: 2020

Type: article

Abstract: Accumulating evidence indicates that cAMP-dependent protein kinase A (PKA) is involved in the neurobiological responses to ethanol. Previous reports indicate that mice lacking the RIIβ subunit of PKA (RIIβ−/−) voluntarily consume more ethanol than wild-type controls (RIIβ+/+) using two-bottle testing procedures. While such procedures primarily measure consummatory behavior, operant self-administration procedures allow analysis of consummatory as well as appetitive or “ethanol-seeking” behavior (i.e., lever pressing is required to gain access to the ethanol solution). Therefore, we determined if the high ethanol consumption characteristic of RIIβ−/− mice would be complimented by increased appetitive ethanol-seeking behavior in an operant paradigm.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/mk6r-1m36

Authors: Sparta, Dennis R., Breese, George R., Knapp, Darin J., Ferraro III, Frank M., Thiele, Todd E.

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Alcohol Abuse and Alcoholism