Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Year: 2020
Type: article
Abstract: Lung infections with Mycobacterium abscessus, a species of multidrug resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF) where they accelerate inflammatory lung damage leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.
Source: UNC Libraries
DOI: 10.17615/434w-g420
Authors: Perry, Audrey, Thomson, Rachel, Drew, Richard J., Desai, Maya, Rodriguez-Rincon, Daniela, Coulter, Chris, Evans, Jason, Bell, Scott C., Jönsson, Bodil, Ruddy, Michael, Modha, Deborah, Robb, Ali, Johnson, Graham R., MacGregor, Gordon, Jabbour, Nassib, Jones, Andrew M., Chapman, Stephen J., O'Brien, Deirdre, Ohri, Chandra, Van Ingen, Jakko, Humphrey, Helen, Everall, Isobel, O'Brien, Christopher, Bourke, Stephen, Sly, Peter D., Pao, Caroline S., Esther, Charles R., Clayton, Andrew, Shafi, Nadia, Noone, Peadar G., Sherrard, Laura J., Denton, Miles, Mayell, Sarah, Giddings, Olivia, Hill, Emily, Bilton, Diana, Morawska, Lidia, Parkhill, Julian, Cullen, Mairi, West, Noreen, Perrin, Felicity, Peckham, Daniel, Whitehouse, Joanna, Bowler, Ian C. J. W., Jones, Andrew, Lillebaek, Troels, Laurenson, Ian, Bryant, Josephine M., Ramsay, Kay A., Kidd, Timothy J., Pandey, Sushil, Prtak, Laura, Brown, Karen P., Stockwell, Rebecca E., Qvist, Tavs, Wainwright, Claire E., Moreno, Pablo, Pressler, Tania, Walshaw, Martin, Nash, Edward F., Wood, Michelle E., Katzenstein, Terese L., Folb, Jonathan, Daniels, Thomas, Andres Floto,, Verma, Deepshikha, Grogono, Dorothy M., Edenborough, Frank, Haworth, Charles S., Schaffer, Kirsten, Dempsey, Owen, Ordway, Diane, Gilligan, Peter, Watson, Danie, Knibbs, Luke D., Isalska, Barbara, Rodgers, Helen, Harris, Simon R., Millar, Michael, Jensen-Fangel, Søren, Drijkoningen, Judith
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4300635347