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IKK-β inhibition prevents adaptive left ventricular hypertrophy

Year: 2020

Type: article

Abstract: Most cardiovascular studies have implicated the central transcription factor nuclear factor kappa B (NF-κB) as contributing to the detrimental effects of cardiac injury. This ostensibly negative view of NF-κB competes with its important role in the normal host inflammatory and immune response. Pressure-overload, left ventricular hypertrophy (LVH), and heart failure represent a spectrum of disease that has both adaptive and maladaptive components. As opposed to its known effects related to myocardial ischemia-reperfusion, we hypothesized that NF-κB is necessary for the compensatory phase of cardiac remodeling.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/b7a8-pf35

Authors: Tang, Ruhang, Andersen, Nancy M., Selzman, Craig H., Javan, Hadi, Li, Ling, Zhang, Xiu Quan

Language: English

Topic: Cardiac Fibrosis and Remodeling

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4300637856

FWCI:

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