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Use of Therapeutic Drug Monitoring, Electronic Health Record Data, and Pharmacokinetic Modeling to Determine the Therapeutic Index of Phenytoin and Lamotrigine

Year: 2020

Type: article

Abstract: Defining a drug's therapeutic index (TI) is important for patient safety and regulating the development of generic drugs. For many drugs, the TI is unknown. A systematic approach was developed to characterize the TI of a drug using therapeutic drug monitoring and electronic health record (EHR) data with pharmacokinetic (PK) modeling. This approach was first tested on phenytoin, which has a known TI, and then applied to lamotrigine, which lacks a defined TI.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/6cjh-3a49

Authors: Ku, Lawrence C., Hill, Kevin D., Gonzalez, Daniel, Guptill, Jeffrey T., Hornik, Christoph P., Cohen-Wolkowiez, Michael, Greenberg, Rachel G., Melloni, Chiara, Wu, Huali, Berezny, Alysha, Zheng, Nan, Jiang, Wenlei

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Pharmaceutical studies and practices

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4300820801

FWCI:

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