Work

Analysis of Hemodynamic Changes and Bold Signals of Sickle Cell Disease Patients during Desaturation

Year: 2015

Type: conference-paper

Abstract: Using nearinfrared spectroscopy (NIRS), previous studies have shown that sicklecell disease (SCD) patients have low cerebral oxygen saturation values. Moreover, the hemoglobin S in sickle cell disease has impaired oxygen carrying capacity. Here, we propose to investigate the effect of induced desaturation on the SCD brain. In particular, we analyzed the falling functional magnetic resonance imaging (fMRI) response during hypoxia, which results from local concentration changes in paramagnetic deoxyhemoglobin (DHB). Moreover, we also explore the nearinfrared spectroscopy (NIRS) changes in oxygenated and deoxygenated hemoglobin from the human prefrontal cortex.

Source: HAL

Authors: Coloigner, Julie, Vu, Chau, Borzage, Matt, Bush, Adam, Lepore, Natasha, Coates, Thomas D., Wood, John

Institutions: Laboratoire Traitement du Signal et de l'Image, Children's Hospital Los Angeles, University of Southern California

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4300838007

FWCI:

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