Work

Kinesin-8 molecular motors: putting the brakes on chromosome oscillations

Year: 2020

Type: article

Abstract: Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo yeast data, these reports reveal how Kinesin-8 molecular motors might control chromosome oscillation amplitudes by spatially regulating the dynamic instability of microtubule plus-ends within the mitotic spindle.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/b999-0b64

Authors: Gardner, Melissa K., Odde, David J., Bloom, Kerry

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W4300909106

FWCI:

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