Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19
Year: 2022
Type: article
Study design: Observational Study
Abstract: Blood neurofilament light chain (NFL) is proposed to serve as an estimate of disease severity in hospitalized patients with coronavirus disease 2019 (COVID-19). We show that NFL concentrations in plasma collected from 880 patients with COVID-19 within 5 days of hospital admission were elevated compared to controls. Higher plasma NFL associated with worse clinical outcomes including the need for mechanical ventilation, intensive care, prolonged hospitalization, and greater functional disability at discharge. No difference in the studied clinical outcomes between black/African American and white patients was found. Finally, vaccination associated with less disability at time of hospital discharge. In aggregate, our findings support the utility of measuring NFL shortly after hospital admission to estimate disease severity and show that race does not influence clinical outcomes caused by COVID-19 assuming equivalent access to care, and that vaccination may lessen the degree of COVID-19-caused disability.
Source: iScience
Authors: Young Erben, Mercedes Prudencio, Christopher P. Marquez, Karen R. Jansen-West, Michael G. Heckman, Launia J. White, Judith A. Dunmore, Casey N. Cook, Meredith T. Lilley, Neda Qosja, Yuping Song, Rana Hanna Al Shaikh, Lillian M. Daughrity, Jordan L. Bartfield, Gregory S. Day, Björn Oskarsson, Katharine A. Nicholson, Zbigniew K. Wszolek, Jonathan B. Hoyne, Tania F. Gendron, James F. Meschia, Leonard Petrucelli
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,000
Awards: Mechanistic insights into the link between the A152T risk variant and tauopathy, Pathophysiology of genetically defined dementia and neurodegeneration: Defining therapeutic targets and pathways, Pathobiology of Neurodegeneration in C9ORF72 repeat expansion, Nuclear Pore Complex and as a Contributor to Tau Associated Dementia, Stathmin-2 and TDP-43 neurodegeneration in Alzheimer’s and multi-etiology dementias, Novel genetic modifiers of C9orf72 and Tau toxicity, Expanding insights into FTD disease mechanisms, ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2), Frontotemporal Dementia: Genes, Images, and Emotions, Discovery of novel TDP-43 splicing targets: the Achilles heel for FTD and towards sensitive biomarkers and therapeutic targets
OpenAlex ID: W4301368568