Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial
Year: 2020
Type: article
Abstract: Use of antiretroviral treatment for HIV-1 infection has decreased AIDS-related morbidity and mortality and prevents sexual transmission of HIV-1. However, the best time to initiate antiretroviral treatment to reduce progression of HIV-1 infection or non-AIDS clinical events is unknown. We reported previously that early antiretroviral treatment reduced HIV-1 transmission by 96%. We aimed to compare the effects of early and delayed initiation of antiretroviral treatment on clinical outcomes.
DOI: 10.17615/m9f6-ph59
Authors: Godbole, Sheela V, Havlir, Diane, Eron, Joseph, Wang, Lei, Celentano, David, Nielsen-Saines, Karin, Hosseinipour, Mina C, Kumwenda, Johnstone, Piwowar-Manning, Estelle, Kumarasamy, Nagalingeshwaran, Mayer, Kenneth H, Essex, Max, Ribaudo, Heather J, Swindells, Susan, Chen, Ying Q, Eshleman, Susan H, Mills, Lisa A, Taha, Taha E, Pilotto, Jose H S, Gallant, Joel, Sanne, Ian, Chariyalertsak, Suwat, de Melo, Marineide Gonçalves, Hakim, James G, Panchia, Ravindre, Ou, San-San, McCauley, Marybeth, Anderson, Maija, Makhema, Joseph, Gamble, Theresa, Hoffman, Irving, Grinsztejn, Beatriz
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4301509372