Year: 2022
Type: article
Abstract: The lifetime of proteins in synapses is important for their signaling, maintenance, and remodeling, and for memory duration. We quantified the lifetime of endogenous PSD95, an abundant postsynaptic protein in excitatory synapses, at single-synapse resolution across the mouse brain and lifespan, generating the Protein Lifetime Synaptome Atlas. Excitatory synapses have a wide range of PSD95 lifetimes extending from hours to several months, with distinct spatial distributions in dendrites, neurons, and brain regions. Synapses with short protein lifetimes are enriched in young animals and in brain regions controlling innate behaviors, whereas synapses with long protein lifetimes accumulate during development, are enriched in the cortex and CA1 where memories are stored, and are preferentially preserved in old age. Synapse protein lifetime increases throughout the brain in a mouse model of autism and schizophrenia. Protein lifetime adds a further layer to synapse diversity and enriches prevailing concepts in brain development, aging, and disease.
Source: Neuron
Authors: Edita Bulovaite, Zhen Qiu, Maximilian Kratschke, Adrianna Zgraj, David G. Fricker, Eleanor J. Tuck, Ragini Gokhale, Babis Koniaris, Shekib A. Jami, Paula Merino-Serrais, Elodie Husi, Lorena Mendive-Tapia, Marc Vendrell, Thomas J. O’Dell, Javier DeFelipe, Noboru H. Komiyama, Anthony Holtmaat, Erik Fransén, Seth G.N. Grant
Institutions: University of Edinburgh, Edinburgh Napier University, University of California, Los Angeles, Consejo Superior de Investigaciones Científicas, Instituto Cajal, Universidad Politécnica de Madrid, University of Geneva, Centre for Inflammation Research, Simons Initiative for the Developing Brain, Science for Life Laboratory, KTH Royal Institute of Technology
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $8,900
Awards: G1208950490, NMDA Receptor Signaling Complexes and LTP, G2642648059, G3188738659, G3487232495, NCCR 'SYNAPSY - The synaptic bases of mental diseases', G434337789, Magnetische Neutronenstreuung bei tiefen Temperaturen, G5675637732, The role of paralemniscal circuits in cortical plasticity and perception, Molecular synapse imaging technology and resources, G8868122451
OpenAlex ID: W4302008264