Work

Particles for Local Delivery of Proteins Using Intra-Articular Route

Year: 2019

Type: article

Abstract: Designing a vehicle for local delivery of proteins using intra-articular route is an attractive option to minimize the adverse effects associated with systemic exposure and to maximize the efficacy. Slowly dissolving silylated microparticles are designed with specific size and shape that are capable of extending the retention time of a model protein (bovine serum albumin) in the murine knee joint. No cytotoxicity is observed for the reconstituted formulation when tested against synovial fibroblasts and RAW 264.7 macrophages.

Source: Carolina Digital Repository (University of North Carolina at Chapel Hill)

DOI: 10.17615/dj1m-s280

Authors: Tian, Shaomin, Khan, Saad A., Luft, James C., Khodabandehlou, Khosrow, DeSimone, Joseph M.

Institutions: University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Advanced Drug Delivery Systems

Subfield: Pharmaceutical Science

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, University of North Carolina at Chapel Hill