ADAM19 and HTR4 Variants and Pulmonary Function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study
Year: 2020
Type: article
Study design: Observational Study
Abstract: The pulmonary function measures of forced expiratory volume in one second (FEV1) and its ratio to forced vital capacity (FVC) are used in the diagnosis and monitoring of lung diseases and predict cardiovascular mortality in the general population. Genome wide association studies (GWAS) have identified numerous loci associated with FEV1 and FEV1/FVC but the causal variants remain uncertain. We hypothesized that novel or rare variants poorly tagged by GWAS may explain the significant associations between FEV1/FVC and two genes: ADAM19 and HTR4.
DOI: 10.17615/fn7w-zr73
Authors: Kovar, Christie L., Zhou, Yanhua, Franceschini, Nora, Muzny, Donna M., Psaty, Bruce M., House, John S., Gibbs, Richard A., North, Kari E., Gharib, Sina A., Heckbert, Susan R., Brody, Jennifer A., Hancock, Dana B., Lumley, Thomas, Morrison, Alanna Cée, London, Stephanie J., Wilk, Jemma B., Gao, Wei, Coresh, Josef
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of Neurological Disorders and Stroke, National Institute of Environmental Health Sciences, National Center for Research Resources, NHLBI Division of Intramural Research
Awards: G1023702118, G1097528416, G1224608327, G1243299691, G125972088, G1401438683, G1438302022, G1527150935, G1565759115, G1691174148, G1726490033, G2109533966, G2193588257, G2432553235, Institute for Clinical and Translational Research (UL1), G250621538, G2555954497, G270907595, G2786044735, G2800149121, G2818913090, G2918387404, G301743239, G3114902838, G3137375862, G3152385821, G3205625555, G3220743633, G322252321, G34347772, G36937976, GWA for Gene-Environment Interaction Effects Influencing CHD, G4167445418, G4200864717, G4219624527, G423252844, The Human Genome Sequencing Center, G4622379297, G4660668308, G4824283243, G4942589162, G4989913237, G5145575165, G517296799, G5251985303, G5281659474, G5386252567, Genome-Wide Association for Loci Influencing CHD and Other Heart, Lung and Blood, G544148272, G5479317095, Epidemiology of Venous Thrombosis and Pulmonary Embolism, G56778789, G567847597, G573134505, CHARGE consortium: omics discovery for CVD and aging phenotypes, G5970815259, G5976719344, G6552090923, G6812537219, G6832344490, G6902273418, G7217924807, G7505613430, G7523983510, G764651519, G766700449, G766843672, G777822606, G806768229, G8068269535, G8260701975, CHS-Transition Phase -268055222, G8892155751, Building on GWAS for NHLBI-disease: the CHARGE consortium, G896633589, G9000027259, G9000046001, G9000069887, G9000124008, G9000124674, G9000139054, G9000155215, G9000294005, From GWAS loci to blood pressure genes, variants & mechanisms - Renewal, G905887895
OpenAlex ID: W4302063532