Year: 2022
Type: article
Study design: Observational Study
Abstract: ABSTRACT Family history is amongst the strongest risk factors for interstitial lung disease (ILD), with emerging evidence for a shared genetic aetiology across ILD subtypes. Recruited families comprised at least two first-degree relatives who had been previously diagnosed with an ILD. All living cases and available unaffected first-degree relatives underwent a clinical examination for evidence of ILD. Preclinical ILD was diagnosed in 47.7% of first-degree relatives who had previously self-reported as unaffected. This study highlights the strong genetic predisposition in family members of ILD cases, and supports the call for routine screening of individuals with a family history of ILD.
Source: Pulmonology
Institutions: University of Tasmania, Menzies Institute for Medical Research, The University of Queensland, Prince Charles Hospital, Prince Charles Hospital, The Alfred Hospital, Alfred Health, Monash University, Royal Adelaide Hospital, The University of Adelaide, Launceston General Hospital, Launceston General Hospital, University of Newcastle Australia, Newcastle University, The University of Western Australia, The University of Sydney, Royal Prince Alfred Hospital, University of Colorado Anschutz, Imperial College London, Fiona Stanley Hospital, Institute for Respiratory Health, Lung Foundation Australia
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4303418521