Sex Differences in Health Conditions Associated with Sexual Assault in a Large Hospital Population
Year: 2022
Type: article
Study design: Observational Study
Abstract: Objective To develop a clinical informatics approach to identify patients with a history of sexual assault and to characterize the clinical risk factors and comorbidities of this population in a sex-stratified manner. Methods We developed and applied a keyword-based approach to clinical notes to identify patients with a history of sexual assault in the Vanderbilt University Medical Center (VUMC) electronic health record from 1989 to 2021. Using a phenome-wide association study (PheWAS), we then examined diagnoses that co-occurred with evidence of sexual assault. We also examined whether sex assigned at birth modified any of these associations. Results Our keyword-based algorithm achieved a positive predictive value of 90.4%, as confirmed by manual patient chart review. Out of 1,703 diagnoses tested across all subgroup analyses, we identified a total of 465 associated with sexual assault, many of which have been previously observed in the literature. Interaction analysis revealed 55 sex-differential phenotypic associations. Conclusions In a large hospital setting, disclosures of sexual assault were associated with increased rates of hundreds of health conditions.
Source: Complex Psychiatry
DOI: 10.1159/000527363
Language: English
Subfield: Gender Studies
Field: Social Sciences
Domain: Social Sciences
Open Access status: hybrid
Funders: National Institutes of Health, National Institute of Mental Health, National Human Genome Research Institute, NIH Office of the Director, National Institute of General Medical Sciences, National Center for Research Resources, Office of Research on Women's Health, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1182793083, Medical Scientist Training Program, Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt, G563474107, G5868276417, Elucidating the phenome-wide impact of sex and gender on disease, The Vanderbilt Institute for Clinical and Translational Research (VICTR) UL1, G7653134492, The Vanderbilt Institute for Clinical and Translational Research (VICTR), G9000033427, G9000300101, Investigating the role of immune genes and inflammatory biomarkers in schizophrenia heterogeneity, Medical Scientist Training Program
OpenAlex ID: W4303470824
